Amphipathic helical structure of Apo E

Non-polar
surface

Polar
surface

Lipoprotein
Surface

small peptides that mimic the structure and function of the receptor binding (polar) and lipid binding (non-polar) domains of Apolipoprotein E. The peptides insert into lipid rich lipoproteins and directs them to receptors on the liver. The lipoproteins are then internalized and degraded, dramatically decreasing blood cholesterol levels.

LipimetiX' lead peptide, AEM-18, is only 18 amino acids, and inserts into LDL as well as VLDL remnants, clearing these cholesterol rich lipoproteins from the blood, even in the absence of the LDL receptor.

AEM-28, is a 28 amino acid peptide that
combines the amphipathic lipid binding
domain of Apo E to the human receptor
binding domain of Apo E

Scientists at the University of Alabama, Birmingham, designed and synthesized